Acute Lung Injury, Children
Conditions
Keywords
acute lung injury, incidence, lung damage, PaO2/FiO2 ratio
Brief summary
Acute lung injury in children is a syndrome of rapid onset of acute respiratory failure and require admission into intensive care units (ICU) for advanced life support. There are almost no information on epidemiology of acute lung injury. Published studies do not have information for an entire year and none of them have evaluated the degree of oxygenation failure under standard ventilator settings. The investigators will perform a 1-year prospective audit of all patients admitted with acute lung injury in a network of pediatric ICUs in Spain.
Detailed description
We will evaluate oxygenation under standard ventilator settings (FiO2 0.5 and 1 on PEEP 5 or 10 cmH2O) in pediatric acute respiratory distress syndrome. Outcome measures will include: overall ICU mortality, number of patients meeting ARDS criteria at 24 hours, and stratification of patients depending on PaO2/FiO2 ratio at 24 h of meeting acute respiratory distress syndrome criteria.
Interventions
OTHEREvaluation oxygenation under standard ventilator settings
Measure of PaO2 under standard FiO2-PEEP
Sponsors
Asociación Científica Pulmón y Ventilación Mecánica
Dr. Negrin University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Months to 18 Years
Healthy volunteers
No
Inclusion criteria
* Acute onset of respiratory failure * Age 1 month to 18 years old * Bilateral pulmonary infiltrates on Chest X-ray * Absence of left ventricular failure, PaO2/FiO2\>300 mmHg
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of cases of acute lung injury per 100,000 population | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of degree of lung severity at onset and at 24 h of the onset of acute lung injury | 1-year |
Countries
Spain
Outcome results
None listed