Cancer, Healthy
Conditions
Keywords
Healthy volunteer
Brief summary
Certain plant foods are high in furanocoumarins. Test tube and animal studies suggest that furanocoumarins may help prevent cancer. It is difficult to determine in humans if furanocoumarins do prevent cancer because there isn't an objective way to tell who has eaten these compounds. This study will develop a urine test to determine if an individual ate foods that contain furanocoumarins.
Interventions
DIETARY_SUPPLEMENTCooked parsnips with parsley
Beginning on Day 9 participants will be given cooked parsnips with parsley at a dose of 2 grams total apiaceous vegetable/kilogram body weight for period 1, and 4 gram/kilogram body weight for period 2.
Sponsors
National Cancer Institute (NCI)
University of Minnesota
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Must be at least 18 years of age * Healthy
Exclusion criteria
* History of gastrointestinal, hepatic or renal disorder * Currently taking any prescription or over-the-counter medication * Currently taking any herbal supplement * Pregnant or lactating * Allergies to foods that will be used (parsnips and parsley)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urinary Biomarker Results for Dietary Furanocoumarins | Week 1 | determine the optimal conditions for furanocoumarin identification and quantification in human urine |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mean Concentration of Dietary Furanocoumarin in Urine | Week 1, 2 and 3 | Determine dose response of dietary furanocoumarin in urine - Comparison of Pre-Dose, Low-Dose and High Dose diet of furanocoumarin in subjects' urine collected (ng/ml). |
Countries
United States
Outcome results
None listed