Sub-total Parathyroidectomy Reduces Vascular Calcification in Haemodialysis Patients

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01140490

Enrollment

Registered

2010-06-09

Start date

2009-01-31

Completion date

2011-12-31

Last updated

2011-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodialysis

Keywords

Hemodialysis, Sub-total Parathyroidectomy

Brief summary

The aim of this study was to evaluate whether successful sub-total parathyroidectomy retards cardiovascular calcification in patients with hemodialysis and to investigate the mechanism .

Detailed description

Hyperparathyroidism (PHPT) in patients with end-stage renal disease have been shown to have an increased morbidity and mortality mainly due to cardiovascular disease. The precise mechanism of cardiovascular disease in PHPT is not well understood . The excess in cardiovascular mortality is significantly and independently related to serum calcium, the connection between the biochemical disturbances and the cardiovascular disorders in PHPT patients is not necessarily a cause-and-effect relationship. Indeed, the impact of surgical cure of hyperparathyroidism on cardiovascular risk factors and mortality is controversial. Some studies suggest that cardiovascular risk markers remained unaltered after Sub-total Parathyroidectomy.

Interventions

PROCEDURESub-total Parathyroidectomy

Sub-total Parathyroidectomy

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* The patients receiving hemodialysis treatment, with elevated intact parathyroid hormone (iPTH) levels \> 800pg/ml on two or more occasions. * Patients with parathyroid nodular or diffuse hyperplasia identified by ultrasound imaging or radioisotope scan.

Exclusion criteria

* Patients with significant background valvular heart disease * Patients who are unfit for general anaesthesia * Patients with acute myocardial infarction within recent two months * Patients with poor general condition * Patients with plans for living related kidney transplant within 1 year * Patients with previous history of parathyroidectomy

Design outcomes

Primary

Measure	Time frame
Change in vascular calcium scores	12 months

Secondary

Measure	Time frame
Change in left ventricular systolic and diastolic function	12 months

Countries

China

Contacts

Primary ContactShi Wei, MD and PHD

shiw_ggh@126.com8602083827812

Backup ContactLiu shuangxin, MD and PHD

mplsxi@yahoo.com.cn8602083827812

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026