Lactic Acidosis, Movement Disorders
Conditions
Keywords
antipsychotics, lactates, side effects
Brief summary
Blood lactate levels in patients receiving typical or atypical antipsychotics have not been described in the literature. The goal of this study is to assess the dynamics of lactate levels in the blood from typical or atypical antipsychotics not confounded by prior antipsychotic treatments, the investigators conducted a prospective study of lactate levels in patients receiving antipsychotic medication. The investigators hypothesized that 6 months of treatment with haloperidol or olanzapine would result in a change in blood lactate levels and extrapyramidal side effects.
Detailed description
The aim of this study was to compare the blood lactate levels in patients receiving typical or atypical antipsychotics. Subjects included sixty patients with psychotic disorder were assigned to treatment for 6 months with haloperidol (typical antipsychotic), N=30 or olanzapine (atypical antipsychotic), N=30. Blood lactate levels, other metabolic parameters, and scores on the extrapyramidal symptom rating scale (ESRS) were assessed.
Interventions
DRUGHaloperidol or olanzapine
Haloperidol tablet - 5 mg twice daily (morning and evening) by mouth Olanzapine tablet - 5 mg twice daily (morning and evening) by mouth
Sponsors
University of Split
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Men aged 20 - 50 years * Not taking any antipsychotic medication 1 month prior to the study * Diagnosed psychotic disorder
Exclusion criteria
* Female * Tobacco use * Diabetes mellitus * Baseline lactate blood level over 2.0 mmol/L
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood lactate levels | 1 month |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Extrapyramidal side effects | 1 month | The extrapyramidal symptom rating scale (ESRS) was used for assessment of four types of antipsychotic induced movement disorders: parkinsonism, akathisia, dystonia, and tardive dyskinesia referred to as extrapyramidal side effects in this study. |
Countries
Croatia
Outcome results
None listed