Leukemia
Conditions
Keywords
childhood acute myeloid leukemia/other myeloid malignancies
Brief summary
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is studying blood and tumor tissue samples from young patients with acute myeloid leukemia.
Detailed description
OBJECTIVES: * To evaluate Mer and Axl expression in samples from pediatric patients with acute myeloid leukemia (AML). * To determine if abnormal expression of Mer and Axl is associated with poor clinical characteristics (e.g., induction failure or relapse) of AML in these patients. OUTLINE: This is a multicenter study. Archived samples from pediatric patients with acute myeloid leukemia are analyzed for Mer and Axl expression by flow cytometry and western blot assays.
Interventions
GENETICgene expression analysis
GENETICwestern blotting
OTHERflow cytometry
OTHERlaboratory biomarker analysis
Sponsors
National Cancer Institute (NCI)
Children's Oncology Group
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 17 Years
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Diagnosis of acute myeloid leukemia * Children Oncology Group (COG) patient samples PATIENT CHARACTERISTICS: * Available clinical data PRIOR CONCURRENT THERAPY: * Not specified
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression of Mer and Axl | — |
| Association of abnormal expression of Mer and Axl with induction failure or relapse | — |
Outcome results
None listed