Chronic Heart Failure, Coronary Disease, Dilated Cardiomyopathy
Conditions
Keywords
chronic heart failure, isokinetic test, near-infrared spectroscopy, laser Doppler flowmetry, endothelial function
Brief summary
Shortness of breath, fatigue, and exercise intolerance are clinical symptoms of chronic heart failure (CHF). Recent studies suggested that peripheral impairment was the major cause of clinical symptoms, and mechanism may be related to neuroendocrine impairment and vascular smooth muscle dysfunction. It results in increased peripheral resistance that may influence limb blood flow, muscle fitness and activities of daily.The purposes of this study are 1. to compare muscular strength, endurance, and perfusion of quadriceps between CHF patients and healthy controls by isokinetic test and near-infrared spectroscopy (NIRS) and difference in activities of daily living 2. to compare endothelium function between CHF patients and healthy control subjects 3. the relationship between endothelium function, muscular strength, endurance, perfusion, and metabolism of quadriceps.
Interventions
None listed
Sponsors
National Taiwan University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
MALE
Age
40 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 40-75 years * Chronic heart failure: ejection fraction\<40% and at stable condition * Coronary Disease and dilated cardiomyopathy without heart failure * Control group without diagnosis of any heart disease
Exclusion criteria
* Clinical diagnosis of neuromusculoskeletal , pulmonary, or other systemic diseases that may affect the testing of the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| muscle strength and endurance | baseline | Measured by biodex |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Walking distance in 6-minute walking test | baseline | walking distance (m) |
| laser Doppler flowmetry combine iontophoresis | baseline | To measure the blood flux (PU) response to Ach (endothelial-dependent agent) and SNP (endothelial-independent agent) |
| skeletal muscle oxygenation response | baseline | Measured by near-infrared spectroscopy |
| questionnaire (functional activity and quality of life) | baseline | — |
| Analysis of venous blood sample | baseline | By standard venipuncture |
| sit-to-stand test | baseline | Measured times in 1 minute |
Countries
Taiwan
Contacts
Primary ContactYing-Tai Wu, Ph.D
Outcome results
None listed