Biomarkers in Patients With Acute Myeloid Leukemia

Mitochondrial Mutations and AML

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01138319

Enrollment

Registered

2010-06-07

Start date

2009-02-28

Completion date

Unknown

Last updated

2015-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Leukemia

Keywords

adult acute myeloid leukemia, childhood acute myeloid leukemia/other myeloid malignancies

Brief summary

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is studying biomarkers in patients with acute myeloid leukemia.

Detailed description

OBJECTIVES: * To determine whether clonally expanded somatic mitochondrial DNA mutations are associated with acute myeloid leukemia. OUTLINE: Genomic DNA from blood samples obtained at diagnosis, remission, and relapse are analyzed for mitochondrial DNA mutations via PCR.

Interventions

GENETICDNA analysis

GENETICmutation analysis

GENETICpolymerase chain reaction

OTHERlaboratory biomarker analysis

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

DISEASE CHARACTERISTICS: * Diagnosis of acute myeloid leukemia * Available blood samples from diagnosis, remission, and relapse PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Design outcomes

Primary

Measure	Time frame
Association between clonally expanded somatic mitochondrial DNA mutations and acute myeloid leukemia	—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026