Tenofovir Renal Toxicity and Glomerular Filtration Rate (GFR) Validation

HIV Infection, Renal Function

HIV, Chronic kidney disease, Glomerular Filtration Rate (GFR), Tenofovir, Serum creatinine (sCr), 24 hr urine creatinine clearance, Serum Cystatin C[40], Modification of Diet in Renal Disease (MDRD), Cockcroft Gault Equation, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), 99mTc-diethylenetriaminepentaacetic acid (Tc-99m DTPA) scan, Validate which renal function assessments can accurately detect GFR and assess the effect of TDF concentration on renal function

To assess and validate equation eGFR in HIV-infected subjects and -uninfected Thai patients

With significant reductions in mortality and risk of progression to AIDS with antiretroviral therapy (ART), complications of long-standing HIV infection and treatment, including renal disease, have become increasingly important. Aging, concomitant metabolic diseases, and use of potentially nephrotoxic ART lead to higher risk for renal disease in HIV-infected persons.WHO encourage TDF as first line ARV regimen. The data on TDF related renal toxicity in Asian population is limited. For this cohort, we plan to look at these topics: 1. proximal tubular dysfunction between TDF and non-TDF user 2. incidence and predictor of TDF related renal toxicity 3. TDF plasma concentrations 4. Pharmacokinetic of TDF when used with boosted DRV, boosted ATV, and boosted LPV in Thai population 5. Bone density and vitamin D in patients with and without hypophosphatemia. 6. Pharmacogenomic of TDF in Thai population

Thailand