Metformin Use and Vitamin B12 Deficiency

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01136512

Enrollment

Registered

2010-06-03

Start date

2007-08-31

Completion date

2008-12-31

Last updated

2013-07-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes Mellitus, Vitamin B12 Deficiency

Keywords

metformin, vitamin B12, type 2 diabetes, methylmalonic acid, deficiency

Brief summary

The primary objective is to determine the incidence of Vitamin B12 deficiency in patients on metformin therapy for diabetes.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

Age 20-80; diagnosed with type 2 diabetes for at least 30 days

Exclusion criteria

known vitamin B12 or folate deficiency; pernicious anemia; on vitamin B12 therapy; hematological malignancy; methotrexate use; alcohol intake greater than two drinks per day; vegetarian diet; previous gastric surgery; inflammatory bowel disease

Design outcomes

Primary

Measure	Time frame
Vitamin B12 level	Single point

Secondary

Measure	Time frame
methylmalonic acid	single point

Countries

United States

Outcome results