Non-small-cell Lung Cancer
Conditions
Keywords
Tumor, Angiogenesis, Exercise training, VEGF, Myostatin
Brief summary
Cancer is one of the leading health issues in this country and worldwide. Angiogenesis is an essential process for tumoral growth and metastasis. This process is dependent on the balance between angiogenic factors and antiangiogenic factors. Muscle wasting has been associated with myostatin overexpression in cancer. Exercise training can depress tumor growth and suppress myostatin expression, and enhance skeletal muscle angiogenesis in healthy people and some animal studies. The purpose of this study is mainly to investigate the effects of exercise training on 1. circulating VEGF-A 2. muscle growth and function 3. Myostatin
Interventions
BEHAVIORALExercise training
Subjects in exercise group will undergo individualized high aerobic interval training on treadmill for 30 minutes under the supervision of an experienced physical therapist 3 times a week and home exercise twice a week with accelerometer.
OTHERUsual care
Subjects in control group will not undergo individualized high aerobic interval training on treadmill. They will receive usual care as normally does in hospital.
Sponsors
National Science and Technology Council, Taiwan
National Taiwan University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Age 40-75 years * Advanced NSCLC * Eastern Cooperative Oncology Group performance status of 0 or 1 * Targeted therapy for at least 8 weeks * Stable condition
Exclusion criteria
* Severe metastasis, cardiopulmonary or musculoskeletal conditions may affect participation in exercise * Do not understand the verbal or written instructions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exercise capacity | 8 weeks after the start of the intervention | Maximal oxygen consumption with Vmax229 Vastus lateral muscle oxygenation with NIRS |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Analysis of venous blood sample | 8 weeks andd 16 weeks after the start of the intervention | Analysis of circulating VEGF-A and myostatin |
| Quality of life | baseline, 8 weeks, 16 weeks | Measured by questionnaire |
| Exercise capacity | 16 weeks after the start of the intervention | Maximal oxygen consumption with Vmax229 Vastus lateral muscle oxygenation with NIRS |
| Imaging of muscle | 8 weeks and 16 weeks after the start of the intervention | Measured by MRS |
| Physical activity | 8 weeks andd 16 weeks after the start of the intervention | Measured with 7-day recall questionnaire |
| Dietary intake | 8 weeks andd 16 weeks after the start of the intervention | Measured with 24-hour recall questionnaire |
| Body composition | 8 weeks andd 16 weeks after the start of the intervention | Body mass index calculated with body weight and height % body fat abd free-fat mass with BIA |
| Muscle function | 8 weeks and 16 weeks after the start of the intervention | Isokinetic muscle strength and endurance with Biodex |
Countries
Taiwan
Outcome results
None listed