Exercise-induced Rise of Body Temperature, X-Linked Hypohidrotic Ectodermal Dysplasia
Conditions
Keywords
hypohidrotic ectodermal dysplasia, exertional hyperthermia, cooling device
Brief summary
Because of their lack of sweat glands individuals with hypohidrotic ectodermal dysplasia (HED) are at particular risk of life-threatening hyperthermia during exercise in a warm environment. In this study, the effects of physical exercise are investigated in boys and male adolescents with X-chromosomally inherited HED as well as age-matched controls, who undergo standardized exertion on a bicycle ergometer at ambient temperatures of 25°C and 30°C. Body core temperature during and after ergometry, heart rate, performance, and serum lactate as a marker of metabolic stress are measured. Subjects with HED are expected to show an endangering rise of body temperature in connection with physical exercise. To clarify, whether novel cooling devices may reduce the likelihood of overheating, the effects of such devices are evaluated at 30°C.
Interventions
DEVICESkin cooling devices
Cooling vest and cooling bandana
Sponsors
Pervormance GmbH
University Hospital Erlangen
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
7 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* for patients: hypohidrotic ectodermal dysplasia caused by EDA gene mutations * regular fluid intake prior to the investigation * written informed consent
Exclusion criteria
* acute febrile illness * acute or chronic heart disease * arterial hypertension * gastrointestinal disorders * implantable electronic devices * MRI investigation scheduled for the 5 days subsequent to the study * clinical signs or diagnostic findings of dehydration
Countries
Germany
Outcome results
None listed