Fractal Analysis of the Pulmonary Arterial Tree in Pulmonary Hypertension

Fractal Analysis of the Pulmonary Arterial Tree in Pulmonary Hypertension.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01135706

Enrollment

Registered

2010-06-03

Start date

2010-04-30

Completion date

2012-02-29

Last updated

2012-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Hypertension

Keywords

Pulmonary Hypertension, Fractal dimension

Brief summary

The investigators propose to confirm that normotensive and hypertensive pulmonary arteries are fractal, as well as define if the FD correlates to disease severity when compared to available data such as six-minute walk and right heart catheterization measurements.

Detailed description

Pulmonary hypertension (PH) is an insidious disorder that can occur in isolation or as a result of various other pulmonary and systemic conditions. If left untreated PH may progress to right heart failure and death. Numerous tests are suggestive but not diagnostic of PH including cardiac echo, pulmonary function testing and chest x-ray. Definitive diagnosis requires right heart catheterization that is invasive, costly and time consuming. The fractal dimension (FD) is an index of the space-filling properties of an object so that the closer the dimension is to the topological dimension in which the object is embedded, the greater the space filling properties. No investigations have been performed to analyze the fractal dimension of pulmonary arteries in patients with PH. We propose to confirm that normotensive and hypertensive pulmonary arteries are fractal, as well as define if the FD correlates to disease severity when compared to available data such as six-minute walk and right heart catheterization measurements.

Interventions

OTHERNo Intervention

This study does not include an intervention but is observational in nature.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients having a right heart catheterization and CT pulmonary angiogram

Exclusion criteria

* None

Design outcomes

Primary

Measure	Time frame
FD of the pulmonary artery in patients with PH will be lower when compared to patients without PH.	24 Months

Secondary

Measure	Time frame
FD will correlate with the degree of PH as quantified by the MPAP obtained during RHC.	24 Months
FD will correlate with the functional capacity of the PH patients as quantified by distance during six-minute walk and NYHA functional class.	24 Months

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026