Role of Diaphragm Fatigue in Weaning From Mechanical Ventilation

Pilot Study on the Role of Diaphragm Fatigue in Weaning From Mechanical Ventilation

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01135121

Enrollment

Registered

2010-06-02

Start date

2010-05-31

Completion date

2016-01-31

Last updated

2015-06-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Muscle Function, Weaning

Brief summary

The purpose of this study is to determine whether the diaphragm develops contractile fatigue during a weaning trial and if this is associated with weaning failure.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* age \> 18 year * mechanical ventilation for at least 3 days * the treating physician judges the patient to be ready to be weaned from the ventilator * informed consent

Exclusion criteria

* pre-existent muscle disease (congenital or acquired) or diseases / disorders know to be associated with myopathy including auto-immune diseases. * upper airway / esophageal pathology (i.e. recent surgery, esophageal varices, diaphragmatic hernia) * recent (\< 1 month) nasal bleeding * phrenic nerve lesions

Design outcomes

Primary

Measure	Time frame
Fatiguability of the diaphragm	Multiple measurements within 24 hours after start of weaning trial

Countries

Netherlands

Contacts

Primary ContactLeo Heunks, MD, PhD

L.Heunks@ic.umcn.nl+31 24 3617273

Outcome results