Intra-uterine Residua
Conditions
Keywords
Retained products of conception, residua, misoprostol, expectant management
Brief summary
The aim of the study is to find out whether conservative treatment - expectant management or medical therapy using misoprostol is beneficial in the case of uterine residua, and which treatment is better.
Detailed description
Retained products of conception are estimated to occur after approximately 1-6% of pregnancies, probably more often after termination of early pregnancies then after term pregnancy. Complication are abdominal pain, infection, bleeding and for the long term - intrauterine adhesions.Blood clots in the uterine cavity can cause similar complications. The definitive treatment is curettage or hysteroscopy, both of which are carried out under general anesthesia and require an operating theater. Although expectant management and uterotonic drugs are practically used in such situation, they are not described in the literature.This study compare between the outcome of misoprostol treatment and expectant management in the case of intrauterine residua after completion of pregnancy.
Interventions
DRUGmisoprostol
8oo mcg intravaginal, second dose after one day if there is no response
Sponsors
HaEmek Medical Center, Israel
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* women with sonographic examination reveals suspicion of intra-uterine residua after completion of pregnancy * intrauterine cavity, including endometrium, will be at least 15mm
Exclusion criteria
* the need for emergency surgical treatment (curettage) * fever - at least 38 celsius degree * women who had medical termination of pregnancy and the examination is after less then 2 weeks since treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| abscence of sonographic finding in the uterine cavity | one week since recruitment | ofter one week, the patients will undergo an US examination.Failure of management defined as uterine cavity width \> 15mm |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Complications | Within one week since recruitment | During the study,there will be collection of data considering pain, bleeding, infection and surgical evacuation. |
| Woman's satisfaction | One week since recruitment | At the end of the week, the patient will be asked about her satisfaction with the treatment |
Countries
Israel
Outcome results
None listed