Skip to content

Dairy Proteins and Postprandial Appetite Regulation and Energy Expenditure

Dairy Proteins and Postprandial Appetite Regulation and Energy Expenditure

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01133964
Acronym
MAES
Enrollment
22
Registered
2010-05-31
Start date
2008-10-31
Completion date
2009-12-31
Last updated
2011-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

Dairy proteins, Appetite regulation, Energy expenditure

Brief summary

The aim of this study is to examine the effect of dairy proteins (whey and casein) on postprandial appetite regulation and energy expenditure.

Detailed description

Several studies have shown that a high protein intake is associated with a increased loss of body weight and body fat as compared to a diet with a normal or low protein content. The effect seems to be due to a higher diet induced thermogenesis and increase satiety. Milk has a high content of proteins. It contains two very different types of protein: whey and casein. Whey is a soluble protein whereas casein clots into the stomach, which delays its gastric emptying and thus probably results in a slower release of amino acids. It is therefore very likely that the two types of protein affect the thermogenesis and appetite regulation differently. The aim of the present study is to examine the effect of dairy proteins (whey and casein) on postprandial energy expenditure, substrate oxidation and appetite regulation. The study will have a cross-over design including four meals each including a test drink (milk, casein drink, whey drink or water).

Interventions

DIETARY_SUPPLEMENTdairy proteins

Protein drinks with 3.5% protein. The protein source will be whey, casein or whey and casein (20:80; normal content in the milk). In the arm with water no protein will be added.

Sponsors

Arla Foods
CollaboratorINDUSTRY
University of Copenhagen
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Investigator)

Eligibility

Sex/Gender
MALE
Age
18 Years to 50 Years
Healthy volunteers
Yes

Inclusion criteria

* healthy males * body mass index (BMI) 25-30 kg/m2 * 18-50 years * weight stable

Exclusion criteria

* smoker * regular use of medicine * elitist athletes * participation in other intervention studies

Design outcomes

Primary

MeasureTime frame
Subjective appetite sensation5 hours
Energy expenditure5 hours
Substrate oxidation5 hours

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026