Acute Respiratory Tract Infection
Conditions
Brief summary
Viral respiratory infections are common worldwide. It has been suggested that nucleic acid amplification tests, enabling a rapid etiologic diagnosis, may be useful in reducing antibiotic prescriptions rates. The objective of this study was to evaluate if access to a multiplex real-time PCR method would have an impact on antibiotic prescriptions for acute respiratory tract infections (ARTIs), in primary care. Adult patients with respiratory tract infections will be prospectively included. Nasopharyngeal and throat swabs will be analyzed with a multiplex real-time PCR method, targeting 13 viruses and two bacteria. Samples will be collected during the winter season (October-April). Patients will be open-label randomised to receive a rapid result (the following day) or a delayed result (after 10+/-2 days). The investigators are planning to include approximately 400 patients. Prescription of antibiotics will be measured at initial visit as well as at a follow-up visit 10+/-2 days later. Primary endpoint is antibiotic prescription in the acute phase (initial visit) and secondary endpoint antibiotic treatment (ongoing or initiated) at follow-up visit. The hypohesis is that access to a method with the ability of providing a rapid etiologic diagnosis of respiratory infections will affect the use of antibiotics in outpatient care of adult patients with ARTI.
Interventions
PROCEDUREAccess to diagnostic test
Randomization to receive a result of diagostic procedure the following day.
Sponsors
Vastra Gotaland Region
Strama - the Swedish strategic programme against antibiotic resistance.
Capio Research Foundation
Göteborg University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 18 years or older * At least two of the following symptoms: coryza, congestion, sneezing, sore throat, odynophagi, cough, chest pain, shortness of breath or fever for which teh physician found no other explanation. * Symptom duration of less than 14 days
Exclusion criteria
* \>14 days of symptoms * confirmed bacterial infection * Hospital acquired infection (\>3days in hospital)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Antibiotic treatment prescriped at initial visit | Within 2 days of initial visit | Antibiotic prescriptions are measured as an outcome of the diagnostic procedure tested. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Antibiotic treatment prescribed or reported at follow-up visit | 10+/-2 days | Antibiotic prescriptions at follow visit are measured as an outcome of the diagnostic procedure tested. |
Countries
Sweden
Outcome results
None listed