Comparative Study of Postprocessing Imaging Systems for Diminutive Colonic Polyps

Prospective Comparison of NBI and i-Scan in Real-time Histological Prediction of Diminutive Colonic Polyps

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01133041

Enrollment

142

Registered

2010-05-28

Start date

2010-05-31

Completion date

2010-10-31

Last updated

2011-09-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adenomatous Polyp, Colonoscopy, Diminutive Colon Polyp, Hyperplastic Polyp

Brief summary

Several novel imaging technologies are currently used for detection and differentiation of colonic polyps during colonoscopy, such as NBI (Olympus), FICE (Fujinon), and i-Scan (Pentax). Several previous studies have indicated that NBI without magnification can be useful for real-time differentiation of diminutive colonic neoplasias. To date, however, there are no studies comparing NBI with other imaging systems (FICE or i-Scan) for differentiation of diminutive colonic polyps. The study objectives are to compare the diagnostic efficacy of NBI with that of i-Scan in real-time prediction of diminutive colonic polyps. In this prospective pilot study, diminutive colonic polyps detected during colonoscopy will be observed with conventional colonoscopy, thereafter will be observed with new imaging systems. Sensitivity, specificity, and diagnostic accuracy of both NBI and i-Scan will be assessed by reference to histological results obtained by endoscopic biopsy or polypectomy.

Interventions

OTHERObservation using NBI system

NBI system can improve the patterns of mucosal surface and vascularity of colonic polyp.

OTHERObservation using i-Scan system

I-Scan system can improve the patterns of mucosal surface and vascularity of colonic polyp.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* screening or surveillance colonoscopy * age over 18 * informed consent

Exclusion criteria

* history of inflammatory bowel diseases * history of hereditary colorectal cancers and polyposis syndrome * inability to give informed consent * use of antiplatelet agent and anticoagulants * pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Diagnostic efficacy	about 1 year	Sensitivity, specificity, and diagnostic accuracy

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026