Role of Inflammation in Progressive Multifocal Leukoencephalopathy (PML)

Role of Inflammation in PML

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01132053

Enrollment

126

Registered

2010-05-27

Start date

2004-06-30

Completion date

2018-12-31

Last updated

2023-08-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Progressive Multifocal Leukoencephalopathy

Keywords

JC Virus

Brief summary

This is a continuation of our previous studies on Progressive Multifocal Leukoencephalopathy (PML). We will focus on the role of inflammation in PML, and define prognostic markers of disease evolution.

Detailed description

To determine precisely what are the host or viral factors that may predict a favorable outcome for PML patients and the role of inflammation in preventing JCV from causing brain disease. One of the goals of this study is to help establish non-invasive markers of PML evolution by studying the brain metabolism in PML lesions using Magnetic Resonance Imaging (MRI), Magnetic Spectroscopy (MRS) and other advanced imaging modalities.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* PML patients of 18 years of age or older will be included in this study.

Exclusion criteria

1. Presence of opportunistic brain lesions other than PML. ( e.g., toxoplasmosis, lymphoma) 2. Presence of confounding neurological disorder such as brain neoplasm etc. In addition patients with a contraindication to MRI examination will be excluded from study. Contraindications to the MRI examination include: 1. Medically unstable or hematological, renal, or hepatic dysfunction. 2. Cardiac pacemaker 3. Internal clips, 4. Metal implants, or external clips with 10 mm of the head. 5. Metal in the eyes. 6. Pregnant 7. Claustrophobia

Countries

United States

Outcome results