Attention Deficit Disorders With Hyperactivity, Attention Deficit Disorder, Hyperkinetic Syndrome
Conditions
Keywords
Attention Deficit Disorders with Hyperactivity, Attention Deficit Disorder, Event related potential
Brief summary
The investigators try to objectively and scientifically explore various brain function impairments in ADHD children by electrophysiologic tests, with and without medication.
Detailed description
The aims of this study are to explore the various cognitive impairments of ADHD children, to differentiate various subtypes of ADHD children, and to investigate the efficacy of anti-ADHD drugs on various cognitive performance of ADHD children by event-related potentials(ERP). Children, aged six to 18 years old, are enrolled and assigned to three groups (normal control, pure ADHD, and ADHD with comorbidities). ADHD children fulfill the DSM-IV-TR criteria for the diagnosis of ADHD. ADHD children are evaluated by Chinese version of SNAP-IV Rating Scale for rating ADHD-related symptoms before and after medication. EEG and audiometric testing are required for every participant to exclude dialeptic seizures and hearing impairment respectively. Methylphenidate (either immediate-release or extended-release formulations) or atomoxetine Hydrochloride is given to ADHD participants.Continuous performance task (CPT) and ERP tasks are applied.
Interventions
DRUGmethylphenidate
IR-MPH were started on a dose of 5 mg tid po, and this was increased to 10 mg tid and then to 15 mg tid as necessary. OROS-MPH was started on a dose of 18 mg qd, and this was increased to 36 mg qd and then to 54 mg qd as necessary.
DRUGAtomoxetine
Atomexetine was started (weight of 70 kg or less) 0.5 mg/kg/day orally and increased after a minimum of 3 days to a target dose of 1.2 mg/kg/day. The maximum dosage is 1.4 mg/kg/day or 100 mg/day (whichever is less).
BEHAVIORALbehavioral modification
Parenting and teaching skill education
Sponsors
Academia Sinica, Taiwan
National Taiwan University Hospital
Far Eastern Memorial Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* health children * or clinical diagnosis of attention-deficit hyperactivity disorder
Exclusion criteria
* hearing impairment * uncorrectable visual impairment * epilepsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chinese version of SNAP-IV Rating Scale | 8 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Event-related potential | 8 weeks |
Countries
Taiwan
Outcome results
None listed