Lung Cancer
Conditions
Keywords
Lung Cancer
Brief summary
The purpose of this study is to determine the validity of a multi-gene Lung Cancer Risk Test (LCRT). In the process, the investigators will establish a bank of NBEC samples and corresponding blood samples from individuals demographically at increased risk for lung cancer.
Detailed description
Because more than 160,000 individuals die of lung cancer/year in the United States alone, it is important to use the best possible methods to determine whether increased surveillance of individuals at highest risk for lung cancer will result in reduced lung cancer mortality. The Lung Cancer Risk Test (LCRT) proposed for evaluation promises to accurately identify the 10-15% of the population that is most susceptible to lung cancer based on genetic predisposition. More than 90 million individuals in the United States alone are demographically at high risk for lung cancer and potential candidates for increased surveillance.
Interventions
GENETICLung Cancer Risk Test
Measurement of gene expression in normal bronchial epithelial cells obtained at time of bronchoscopy.
Sponsors
National Cancer Institute (NCI)
University of Toledo Health Science Campus
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* 20 or more pack year smoking history * clinical need for diagnostic bronchoscopy or consent to study driven bronchoscopy
Exclusion criteria
* Lung Cancer within 3 months after the date of enrollment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Accuracy of LCRT to predict incidental lung cancer | from time of enrollment | Time of diagnosis of incidental lung cancer will be compared to value of the investigational device, the Lung Cancer Risk Test (LCRT). |
Countries
United States
Outcome results
None listed