The Effects of Plant Bioactives on Platelet Function

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01130129

Enrollment

Registered

2010-05-25

Start date

2010-06-30

Completion date

2011-06-30

Last updated

2013-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Flavonoids, Platelets

Brief summary

Consumption of a diet rich in fruit and vegetables is associated with a reduced risk of cardiovascular disease and the protective effect may be due to polyphenolic compounds contained within these foods. The mechanism by which polyphenols exert this effect is not clearly understood but research has focused on their potential to affect platelet function. The purpose of this study is to quantify the anti-clotting activity of a range of plant food extracts and component compounds.

Detailed description

A single sample of whole blood will be collected from 15 male or female volunteers aged between 18 and 65 years. After collection whole blood will be treated with a range of flavonoids to evaluate their effects on platelet function.

Interventions

OTHEREx-vivo treatments with flavonoids

Ex-vivo treatment of platelets with a range of flavonoids

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Males and females * Aged 18 - 65 years. * BMI \> 19.5 and \< 35 * Non-smokers

Exclusion criteria

* Pregnancy or have been pregnant within the last 12 months * Parallel participation in another research project which involves dietary intervention * Participation in another research project which has involved blood sampling within the last four months unless the total amount of combined blood from both studies does not exceed 470 mls. * Has donated or intends to donate blood within 16 weeks prior to during the Study period. * Depressed or elevated blood pressure measurements (\<90/50 or 95/50 if symptomatic or \>160/100) * Any person related to or living with any member of the study team * Diabetics * Taking regular prescribed and/or non-prescribed medication (excluding oral contraceptive and HRT). * Known bleeding disorders.

Design outcomes

Primary

Measure	Time frame
Identification of flavonoids that exert a significant anti-clotting effect	within 4hours

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026