Mothers With a History of Depression and Their 10-14 Year Old Daughters

The Neural Correlates of Mood and Cognitive Bias in a Population at Risk for Depression: Maternal Cognitive and Emotional Functioning

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01129752

Enrollment

240

Registered

2010-05-25

Start date

2004-02-29

Completion date

2011-04-30

Last updated

2011-06-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression, Depressive Disorder, Major

Brief summary

The purpose of this study is to investigate risk factors associated with depression and how such factors might be transmitted cross-generationally. The investigators are conducting an integrative assessment of emotion regulation and stress reactivity in a group of mothers with and without a history of depression and their daughters.

Detailed description

The purpose of this study is to investigate risk factors associated with depression and how such factors might be transmitted cross-generationally. We are conducting an integrative assessment of emotion regulation and stress reactivity in a group of mothers with and without a history of depression and their daughters. We use a range of methodologies to evaluate these processes, including self-report measures, information-processing performance, HPA-axis functioning and reactivity, and neural responses to emotional stimuli following exposure to stressful experiences.

Interventions

OTHERNo intervention

there is no intervention for this study

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

9 Years to 15 Years

Healthy volunteers

Yes

Inclusion criteria

* Eligible mothers must read and speak English fluently and have a child between the ages of 9 and 15 years old. * Mothers must either have no history of psychopathology or have a history of depression during their child's lifetime.

Exclusion criteria

* Eligible mothers cannot: * currently be in treatment for drug or alcohol abuse * have significant symptomatology related to psychopathology outside of depression * have a medical history of neurological injury or impairment. * Mothers who meet the requirements for inclusion in the control group must not have a history of any Axis I disorder.

Design outcomes

Primary

Measure	Time frame	Description
Onset of depression	18 months	participants are interviewed in an 18-month follow-up session

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026