Pilot Study of Remote Ischemic Preconditioning in Heart Failure

Effect of Remote Ischemic Preconditioning on Exercise Capacity in Patients With Heart Failure: A Double Blind Randomized Control Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01128790

Enrollment

Registered

2010-05-24

Start date

2009-10-31

Completion date

2011-06-30

Last updated

2013-12-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure, Left Ventricular Dysfunction

Keywords

exercise, remote ischemic preconditioning, heart failure, left ventricular dysfunction

Brief summary

The purpose of this study is to determine the effect of remote ischemic preconditioning on exercise capacity in patients with heart failure.

Interventions

OTHERRemote ischemic preconditioning

4 cycles x 5 mins upper limb blood pressure cuff inflation 20mmHg above systolic blood pressure

OTHERSham Control

4 cycles x 5mins blood pressure cuff inflation to 10mmHg

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* LV ejection fraction \<40% * NYHA functional class II-IV * Non ischemic cardiomyopathy * Stable

Exclusion criteria

* recent cardiovascular hospitalization (within last 4 weeks) * ischemic cardiomyopathy * diabetes mellitus * peripheral neuropathy * ventricular assist device * contraindications to exercise stress testing

Design outcomes

Primary

Measure	Time frame
Exercise performance - VO2, exercise time, exercise workload, anaerobic threshold	1 week

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 7, 2026