Acute Pancreatitis
Conditions
Keywords
Acute pancreatitis, Enteral nutrition, Pancreas rest
Brief summary
Pain relapse during oral refeeding occurs in at least one-fifth of patients with acute pancreatitis. The study hypothesis is that early administered enteral tube feeding might reduce a risk of pain relapse and shorten the length of hospital stay in patients with acute pancreatitis.
Interventions
PROCEDUREEnteral tube feeding
Nasogastric tube feeding started within 24 h of hospital admission
Sponsors
University of Auckland, New Zealand
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* diagnosis of acute pancreatitis * age 18 years or older * written informed consent
Exclusion criteria
* \> 96 hours after onset of symptoms * \> 24 hours after hospital admission * organ failure by the time of randomization * infectious complications before randomization * received artificial nutrition before randomization * previously enrolled into the trial * chronic pancreatitis * post-ERCP pancreatitis * intraoperative diagnosis of acute pancreatitis * pregnancy * malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Length of hospital stay | Up to 3 months |
Secondary
| Measure | Time frame |
|---|---|
| Local and systemic complications | Up to 3 months |
| Feeding intolerance | Up to 3 months |
| Time to solid oral food tolerated | Approx. one week |
| Pain relapse | Up to 3 months |
| Hospital readmission | Up to 6 months |
| Quality of life | Up to 6 months |
| Mortality | Up to 6 months |
| Pain-free time | Up to 3 months |
Countries
New Zealand
Outcome results
None listed