Stress Reduction and Anxiety: Effects on the Function and Structure of the Brain

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01128309

Enrollment

Registered

2010-05-21

Start date

2010-05-31

Completion date

2011-04-30

Last updated

2012-05-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Generalized Anxiety Disorder

Brief summary

The aim of the study is to test whether Generalized Anxiety Disorder (GAD) patients that participate in a Stress Reduction Intervention show a brain activation pattern (assessed by MRI) indicative of improved emotion regulation compared to an active control intervention.

Interventions

BEHAVIORALStress Reduction Intervention

eight week group program, plus daily homework practice

BEHAVIORALActive Control intervention

weekly group meetings for eight weeks, plus daily homework practice

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* participation in the study 'Stress Reduction Techniques and Anxiety: Therapeutic and Neuroendocrine Effects by Dr. Elizabeth Hoge

Exclusion criteria

* metallic implants * left handed * epileptic seizures * head trauma * weight over 350 pounds * claustrophobia

Design outcomes

Primary

Measure	Time frame	Description
brain activation and structure as assessed by MRI	Day 1 (within two weeks before the intervention)	BOLD functional MRI and structural MRI

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026