The Effect and Mechanisms of the Second-meal Phenomenon in Type 2 Diabetic Patients

The Effect and Mechanisms of the Second-meal Phenomenon in Type 2 Diabetic

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01127997

Enrollment

Registered

2010-05-21

Start date

2010-03-31

Completion date

2010-08-31

Last updated

2010-08-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes

Brief summary

Second-meal phenomenon denotes the effect of a prior meal in decreasing the rise in blood glucose after a subsequent meal. This phenomenon occurs in normal subjects while it is not clear whether it is also observed in type 2 diabetic patients. This study aims to define whether the second-meal phenomenon occurs in type 2 diabetic patients. We will also seek for the mechanism.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

35 Years to 70 Years

Healthy volunteers

Inclusion criteria

* age 35-70 * HbA1c 6-8% * DM duration less than 5 yrs

Exclusion criteria

* type 1 DM, secondary DM, gestational DM * patients using insulin, TZDs * patients using corticosteroid, herb medication or other medications affecting glucose tolerance * renal dysfunction (Cr \> 1.5mg/dL) * hepatic dysfunction (LFT \> x 3UNL) * anemia (Hg \< 10g/dL) * ischemic heart disease, congestive heart failure * severe diabetic complication (CRF, CVA, PDR, gastroparesis) * infectious disease * malignancy * pregnant women

Design outcomes

Primary

Measure	Time frame	Description
Area under the curve of plasma glucose after meal	3 months	Compare the post-lunch AUC of glucose between two meal tolerance tests(one after having breakfast, one after not having breakfast)

Secondary

Measure	Time frame	Description
the mechanism of second-meal phenomenon	3 months	serum FFA, plasma insulin, C-peptide, incretin concentration will be measured

Countries

South Korea

Outcome results