Study to Evaluate the Effectiveness of High Dose Statin Loading in Acute Heart Failure Patients

A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Evaluate the Effectiveness of High Dose Statin Loading in Acute Heart Failure Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01127945

Enrollment

Registered

2010-05-21

Start date

2010-05-31

Completion date

2013-11-30

Last updated

2014-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Heart Failure

Brief summary

This is a prospective, single-center, randomized, controlled, open-label, pilot study to evaluate the effectiveness of high dose statin loading in acute heart failure patients.

Interventions

DRUGstatin

1. adding atorvastatin 80mg, po on day (1 to 3) acute heart failure therapy 2. acute heart failure therapy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Dyspnea at rest or minimal activity * Tachypnea (respiratory rate \> 20/min) or rales or pulmonary edema on chest X-ray

Exclusion criteria

* Acute coronary Syndrome * Hospitalization plan for PTCA or CABG * Cardiogenic shock (Systolic Blood Pressure \< 80mmHg) * Uncontrolled hypertension (Systolic Blood Pressure \> 180mmHg) * Allergy, adverse drug reaction, hypersensitivity to statin * Troponin \> 5 times upper limit of normal (ULN) * Creatinine kinase-MB level \> 3 times ULN * AST, ALT \> 3 times ULN or acute hepatitis * Current or past history of muscle disease, rhabdomyolysis * Life expectancy \< 6 months (e.g. metastatic malignancy, liver cirrhosis) * Pregnancy or women at age of childbearing potential

Design outcomes

Primary

Measure	Time frame	Description
hsCRP levels	at hospital day #4	to investigate the effect of high dose statin loading on the change of serum NT-proBNP, hsCRP levels in patients with acute heart failure

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026