Pilot Study Using Echocardiography to Evaluate Patients With Heart Failure and Dyssynchrony Who Have a CRT-D Device

Validation of a Robust Method for Kinematic Analysis of Ventricular Mechanical Dyssynchrony by Two Dimensional Echocardiography in Patients With Cardiac Resynchronization Devices for Chronic Systolic Heart Failure and Conduction System Disease

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01127334

Enrollment

Registered

2010-05-20

Start date

2010-05-31

Completion date

2011-05-31

Last updated

2012-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Systolic Heart Failure

Keywords

Dyssynchrony, Cardiac resynchronization therapy

Brief summary

Out of all the patients that receive a CRT-D ( a dual chamber pacemaker with defibrillator ) for cardiac resynchronization therapy there is approximately one-third that do not respond. We believe that by using a simple technique that includes routine echocardiography that are normally performed in these patients could help us better understand how to program their device to reach better optimization.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Adults age 18-110 years 2. Must have a CRT-D (A biventricular pacemaker with defibrillator) 3. Last optimization of their device (CRT-D) must not have been done in the past 3 months 4. Must be optimal heart failure medical regimen. This includes target dose of beta-blocker and angiotensin converting enzyme inhibitor (ACE-I) (or equivalent; i.e angiotensin receptor blocker (ARB); or balanced preload and afterload reducers with hydralazine and nitrates.)

Exclusion criteria

1. Less than 18 years of age or greater than 110 years old. 2. Does not have a CRT-D 3. Optimization of their device has occurred in the past 3 months 4. Not on optimal medical therapy for heart failure as listed in the inclusion criteria.

Countries

United States

Outcome results