H1N1 Influenza
Conditions
Keywords
influenza, vitamin, improvement of symptom
Brief summary
Influenza continues to inflict an important burden on health-care systems. The 2009 H1N1 influenza virus first appeared in Mexico and the United States in March and April 2009 and has swept the globe with unprecedented speed. The aim of this study is to evaluate effect of supplement vitamin on the clinical course of patients with acute respiratory illness suspected novel H1N1 infection.
Detailed description
Patients with acute respiratory illness randomized to control or vitamin groups. The patients completed questionnaire about their initial symptom scores. After 5 days of vitamin trial, patients were asked about their symptom by telephone survey.
Interventions
DRUGVitamin (vitamin A 15 mg,C 500 mg, E 400IU)
Vitamin (vitamin A 15 mg,C 500 mg, E 400IU) 1T po for 5 days in addition to anti-viral agent and antipyretics
DRUGPlacebo (digestive tablet)
Placebo (digestive tablet) 1T po for 5 days in addition to anti-viral agent and antipyretics
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 20 years * Acute respiratory illness suspected H1N1 infection * Acute febrile respiratory illness(BT \> 37.8) and throat pain or cough or nasal congestion
Exclusion criteria
* Pregnancy * Hypersensitivity to vitamin A * History of liver disease or renal disease * Urinary stone disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change of symptom score | 1 week after initial visit |
Countries
South Korea
Contacts
Primary ContactChang-Hoon Lee, MD
Backup ContactJong Sun Park, MD
Outcome results
None listed