Characterization and Differential Diagnosis of Vertebral Osteomyelitis

Clinical Features, Microbiological-, Radiological Characteristics, and Differential Diagnosis of Vertebral Osteomyelitis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01125839

Enrollment

100

Registered

2010-05-19

Start date

2010-05-31

Completion date

2013-12-31

Last updated

2014-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vertebral Osteomyelitis

Keywords

osteomyelitis, 16S rRNA, spine, Magnetic resonance imaging

Brief summary

Vertebral osteomyelitis is a uncommon disease that can lead to neurologic deficits if not diagnosed in time. The etiologies of vertebral osteomyelitis include pyogenic bacteria, M. tuberculosis, Brucella species, and fungus. The aim of this study is to describe the clinical features and microbiological/radiological characteristics of patients with vertebral osteomyelitis, and investigate the useful tips for the differential diagnosis of vertebral osteomyelitis.

Detailed description

Besides description of characteristics of patients with vertebral osteomyelitis, we also will investigate the usefulness of 16S rRNA gene sequence analysis of biopsy specimen. MRI findings during the antibiotic treatment will be monitored and compared for the differential diagnosis of meningitis.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

16 Years to No maximum

Healthy volunteers

Inclusion criteria

* Symptoms or signs consistent with spinal column infection * MRI findings suggestive of infection * Antibiotic treatment for vertebral myelitis

Exclusion criteria

* Patients already treated more than 2 weeks for osteomyelitis in transferring hospital

Design outcomes

Primary

Measure	Time frame
Identification of etiology of vertebral osteomyelitis	within 6 weeks after the diagnosis of vertebral osteomyelitis

Secondary

Measure	Time frame
Unfavorable outcomes (death or permanent neurologic deficit)	within 6 months after the diagnosis of vertebral osteomyelitis

Countries

South Korea

Outcome results