Memory Study of Youngest Women Enrolled in the Women's Health Initiative Hormone Therapy (HT) Arm

Women's Health Initiative Memory Study of Younger Women

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01124773

Acronym

WHIMS-Y

Enrollment

1362

Registered

2010-05-17

Start date

2009-06-30

Completion date

2016-06-30

Last updated

2017-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dementia

Keywords

cognition, memory, hormone therapy

Brief summary

WHIMS-Y provides valuable information on the long-term effects on risk of cognitive impairment of hormone therapy in a subset of WHI participants in the WHI Hormone Trials. Following cessation of study-prescribed HT cognitive function and impairment were assessed.

Detailed description

The Women's Health Initiative Memory Study of Younger Women (WHIMS-Y) is proposed to assess the long-term impact of random assignment to postmenopausal hormone therapy (equine estrogen alone or in combination with medroxyprogesterone versus placebo) among women who were aged 50-54 at the time of randomization into the WHI hormone trials. Secondary objectives relate to the consistency of any treatment effects across unopposed or opposed therapy and whether there exists evidence of graded relationships between cognitive effects and age of administration, years from menopause, and baseline risk factors for cognitive impairment.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

50 Years to 54 Years

Healthy volunteers

Yes

Inclusion criteria

* Must be enrolled in the Women's Health Initiative Extension

Exclusion criteria

* Not enrolled in the Women's Health Initiative Extension

Design outcomes

Primary

Measure	Time frame	Description
All-cause dementia and Mild Cognitive Impairment	Measured once a year	Participants will have a cognitive assessment administered over the telephone.

Secondary

Measure	Time frame	Description
Global and domain specific cognitive function.	Measured once a year	Participants will have a cognitive assessment administered over the telephone.

Countries

United States

Outcome results