CARCINOMA LARYNX, CARCINOMA OROPHARYNX, CARCINOMA PYRIFORM SINUS, HEAD AND NECK CANCER
Conditions
Keywords
IGRT, 3DCRT, EPID, CBCT, HNSCC
Brief summary
This study aims to study the impact image guided radiotherapy with Cone beam CT will have on the outcomes(toxicities and response) of head and neck cancer when compared to 3D conformal radiotherapy without CBCT based setup error verification.Also,the various dosimetric variations in Adaptive RT will be studied.
Detailed description
Aims and Objectives 1. To assess the patient's radiation dose planning for GTV, CTV and PTV for primary and nodal regions and derive comparison between IGRT and 3D-CRT. 2. To assess the dosimetric variation in different phases of adaptive RT due to changes in tumor shape and volume during the course of entire treatment in IGRT arm in head and neck cancer patients. 3. To evaluate the optimal setup correction methodology using planar (EPID) and volumetric images (CBCT) in HNSCC between 3D-CRT and IGRT treatment delivery respectively. 4. To compare the early tumour response and acute and chronic radiation morbidities between IGRT and 3D-CRT.
Interventions
RADIATIONEPID Verification
Set up error verification and correction by EPID
RADIATIONCBCT verification
Setup error verification and correction by CBCT
Sponsors
All India Institute of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Histopathologically proven cases of Carcinoma Oropharynx,Larynx,Hypopharynx, stages T1-4 N0-2a M0 * Informed Consent * KPS score \> 70
Exclusion criteria
* Uncontrolled medical comorbidity * Not ready for follow up * Previous cancer directed therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| compare the early tumour response between 3DCRT and IGRT in head and neck cancer. | Assessment at post RT week, 1 month after completion of RT and 6 month after completion of RT. Final assessment of last recruited patient is anticipated to be by AUGUST 2011 | The advent of CBCT has increased the verification of Radiation treatment delivery but whether it leads to significant change in tumour response or toxicities when compared to 3D Conformal Radiotherapy without CBCT verification is not known.This study will give insights into this question. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To assess and compare early and late toxicities between 3DCRT and IGRT in head and neck cancer | assessment of acute and chronic toxicities of the last recruited patient anticipated to be by March 2011 | Assessment will be done by RTOG scoring criteria |
| To find out the different doses received by target and organs at risk during the various phases of adaptive RT. | last measurement by AUG 2011 | — |
Countries
India
Outcome results
None listed