Postoperative Nausea and Vomiting
Conditions
Brief summary
The purpose of this investigator-initiated study is to see if giving dextrose fluid in the veins (IV) decreases the risk of postoperative nausea and vomiting (PONV) in female urologic, gynecologic and breast outpatient surgery patients and at what blood surgery level. The reason for this study is that IV dextrose has been shown to decrease the incidence of PONV and the use of medications to treat PONV, while leading to sooner discharge after surgery. This can decrease overall healthcare cost and improving patient satisfaction.
Interventions
OTHERIntravenous fluid
The treatment group will receive a 250cc bolus over 2 hrs of D5LR prior to the end of surgery and continued in the PACU. Blood glucose will be checked 3 different times using an Accu-chek monitor along with the type and number of rescue medications given at 30, 60, and 120 minutes after anesthesia and the post-op morning. The control group will receive a 250cc bolus over 2 hours of LR. Blood glucose will be monitored 3 times along with the type and how much of rescue medications are given at 30, 60 and 120 minutes post-op and the morning after surgery.
OTHERD5LR or lactated ringers
The purpose of the study is to see if giving dextrose fluid in the veins (IV) decreases the risk of postoperative nausea and vomiting (PONV) in female urologic, gynecologic and breast outpatient surgery patients and at what blood sugar level. The reason for this study is that IV dextrose may decrease the incidence of PONV and the use of medications to treat PONV, while leading to sooner discharge after surgery. This can decrease overall healthcare cost and improving patient satisfaction.
Sponsors
Loma Linda University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
1. ASA I or II 2. female urologic, gynecologic and breast surgery patients undergoing scheduled same day procedures at LLUMC Heart and Surgical Hospital
Exclusion criteria
1. age \<18 or \>65; 2. severe hypertension,diabetes mellitus, significant hepatic or renal disease 3. excessive blood loss 4. sustained (\>10 min)\>20% from baseline drop in BP after treatment 5. inability to follow protocol 6. refusal to sign consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| A Closer Look at the Effect of Glucose on Postoperative Nausea and Vomiting | approximately 24 hours | The primary outcome measures will be the severity and incidence of PONV along with the type and number of rescue medications given at 0,30,60, and 120 minutes PACU time and the next morning. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| A Closer Look at the Effect of Dextrose on Post-operative nausea and vomiting | approximately 24 hours | Secondary endpoints recorded will be length of surgery, history of PONV, amount of pain medicine administered, blood loss, drop in BP \> 20%, unplanned hospital admission for PONV, and time till ready for discharge from PACU. |
Countries
United States
Outcome results
None listed