Angina Pectoris
Conditions
Brief summary
60 elective patients for CABG will be included to receive either standard hyperkalemic cardioplegia (St.Thomas Hospital Solution No I) or cardioplegia where supranormal potassium is replaced with 1.2 mM adenosine. Hypothesis as follows: 1. Adenosine instead of supranormal potassium in the cardioplegic solution give satisfactory cardiac arrest. 2. Adenosine instead of supranormal potassium in the cardioplegic solution gives equal cardioprotection. The patients will be followed with PiCCO-catheter to monitor cardiac function and repetitive blood samples to measure release of cardiac enzymes.
Interventions
DRUGAdenosine
1.2 mM adenosine instead of supranormal potassium in the cardioplegic solution
Sponsors
University Hospital of North Norway
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Elective patients * Ejection fraction \> 40% * Age 40-75 * No release og TnT or CKMB within last week before CABG * Pure CABG
Exclusion criteria
* Age \>75 or \< 40 * EF \< 40% * Emergency operations * Unstable angina * Release of TnT or CKMB within the week before operation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Release of cardiac enzymes (TnT and CKMB) | First 48 hour postoperatively | Repeatedly measured postoperatively. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| PiCCO | First 24 hours postoperatively | Measurement of cardiac function and hemodynamics the first 24 hours postoperatively |
| Endothelial injury | Peroperatively (before crossclamping aorta and after 5 minutes of reperfusion) | Measurements of markers of endothelial injury/dysfunction peroperatively. Blood will be sampled immediately before cross-clamping the aorta and after 5 minutes of reperfusion. |
Countries
Norway
Outcome results
None listed