Influence of Adiponutrin in Chronic Liver Disease

Study of Metabolism Influence in Human Alcoholic Liver Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01122797

Enrollment

658

Registered

2010-05-13

Start date

2003-01-31

Completion date

2010-03-31

Last updated

2010-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcoholic Liver Disease

Keywords

PNPLA3, fibrosis, cirrhosis, alcoholic liver disease

Brief summary

Increasing evidence attests the influence of multiple metabolic genetic risk factors in the progression of alcoholic liver disease. Deleterious pathways involved in metabolism such as lipid peroxidation and cytokines have been implicated in promoting inflammation leading to fibrosis increase and liver injury progression. The aim of this study was to assess the role of rs738409 single nucleotide polymorphism in the PNPLA3 gene in alcoholic liver disease patients.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

ALD patients: Inclusion Criteria: * Excess alcohol intake * Abnormal alanine aminotransferase (ALT) and aspartate aminotransferase (AST) or a suspicion of cirrhosis related to ALD * Caucasian ethnicity

Exclusion criteria

* Presence of any other chronic liver disease * Co-infection with human immunodeficiency virus Controls: Inclusion Criteria: * Caucasian ethnicity

Design outcomes

Primary

Measure	Time frame	Description
Assessment of fibrosis and steatosis by liver biopsy in alcoholic liver disease patients.	—	After liver histology assessment for liver liver dammage a potential correlation of fibrosis and steatosis was studied with rs738409 PNPLA3 polymorphism

Countries

Belgium

Outcome results