Neurosurgery
Conditions
Keywords
Meningitis, infection, cerebrospinal fluid, procalcitonin, adenosine deaminase
Brief summary
Meningitis is a rare complication following neurosurgical procedures and is associated with high morbidity and mortality. The aim of this study is to describe the clinical characteristics and microbiological characteristics in patients who develope meningitis following neurosurgical operations, and investigate the useful tips for the differential diagnosis of postneurosurgical meningitis.
Detailed description
Besides description of characteristics of patients with postneurosurgical patients, we also will investigate the usefulness of prolonged cerebrospinal fluid (CSF) culture, and profiles of blood and CSF inflammatory markers for the differential diagnosis of meningitis. CSF culture will be extended upto 2 weeks. Serum procalcitonin and C-reactive protein, CSF adenosine deaminase levels will be monitored and analyzed for the differential diagnosis of meningitis.
Interventions
None listed
Sponsors
Asan Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Cerebrospinal fluid corrected WBC \>6/mm\^3 and/or fever (\> 38℃) and/or neck stiffness
Exclusion criteria
* Patients already treated more than 48 hours for meningitis before cerebrospinal fluid examination
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Development of meningitis | within 4 weeks after neurosurgical operation |
Secondary
| Measure | Time frame |
|---|---|
| All-cause mortality | within 4 weeks after the diagnosis of meningitis |
Countries
South Korea
Outcome results
None listed