Age-related Cognitive Decline
Conditions
Keywords
Cognitive Aging, Apolipoproteins E, Magnetic Resonance Imaging
Brief summary
The primary purpose of this study is to apply state-of-the-art Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopic Imaging (MRSI) techniques to measure changes over time in the brain.
Detailed description
We expect that MRI and MRSI techniques will be a useful adjunct in research efforts to understand individual differences in performance of a complex attention-demanding task, such as flying a plane or driving a car. Other predictors of change in performance of a complex task may include simple tests of processing speed and working memory, past training and recent practice of the task, and genetic risk factors for degenerative brain disease. In this project, we will examine whether baseline MR measures are as useful as longitudinal MR measures in predicting amount of change over time in task performance. This research is part of a long-term effort to achieve earlier identification of individuals at risk of decline and ultimately minimize loss of function.
Interventions
DEVICEMRI
MRI - routine imaging sequences, designed for anatomical quantification
Sponsors
Palo Alto Veterans Institute for Research
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
45 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Subjects will be included if they have participated in the protocol Age-Related Longitudinal Changes in Aviator Performance and agree to participate in this protocol.
Exclusion criteria
* Subjects will be excluded if they currently have a major neurological disease, unstable/untreated medical disease (such as untreated hypertension). * In consideration of the magnetic fields in which subjects will be placed for the MR scanning, we will also exclude subjects who are unable to safely and comfortably complete the scanning session. This includes individuals who are wearing any metal prosthesis or who have cardiac pacemakers or any other nonremovable metal objects. * Subjects reporting a history of severe claustrophobia or poorly controlled back pain will be excluded because it is unlikely they could comfortably remain still in the MRI scanner for the duration of the scan. * In addition, subjects who do not fit in the apparatus will also be excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| flight simulator performance summary score | yearly for up to 6 years | z-score composite of executing ATC communications, avoiding traffic, monitoring engine malfunctions, visual approach and landing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| CogScreen-AE | yearly | computerized battery (assesses processing speed, executive function, paired assoc memory, n-back task, psychomotor tracking |
| Salthouse processing speed measures | yearl | digit copy & pattern comparison |
Countries
United States
Outcome results
None listed