Acute Myocardial Infarction
Conditions
Keywords
Myocardial Infarction, Percutaneous Coronary Intervention, Acetaminophen, Lipid Peroxidation
Brief summary
The purpose of this study is to test the hypothesis that acetaminophen will reduce lipid peroxidation and isoprostane formation during reperfusion after percutaneous revascularization for acute myocardial infarction.
Interventions
DRUGAcetaminophen
single dose
DRUGPlacebo
single dose
Sponsors
Vanderbilt University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- Patients presenting with STEMI
Exclusion criteria
* Duration of symptoms \> 12 hours * Suspected LM or proximal LAD occlusion (based on EKG interpretation) * Hemodynamic instability * Acetaminophen use in prior 24 hours * Use of dipyridamole, or Aggrenox, a formulation of aspirin and extended-release dipyridamole, within 48 hours * Current use of the following medications: phenytoin, valproic acid, phenobarbital, topiramate, rifampin, carbamazepine, cyclophosphamide, ritonavir, efavirenz, St. John's Wort * Chronic heavy alcohol use * Chronic liver disease (other than non-alcoholic fatty liver infiltration) * Severe valvular heart disease * Stroke in the past 60 days * Active major bleeding * Major surgery in the past 30 days * Ongoing treatment for active malignancy * Life expectancy less than 12 months as determined by the patient's attending physician * Pregnancy * asthma or severe COPD * active wheezing on presentation * allergy or prior adverse reaction to adenosine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma isoprostane level | 60 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Index of microcirculatory resistance | Average 20 minutes |
Countries
United States
Outcome results
None listed