Metabolic Syndrome
Conditions
Keywords
hepatic fat content, hepatic de novo lipogenesis
Brief summary
10 healthy male volunteers will be studied after * a 6 day weight maintenance, balanced diet * a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day * a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day and 20g amino-acids per day At the end of each 6 days period, the following measurements will be obtained * intrahepatic lipids (1H-MRS) * metabolic effects of fructose ingestion (measurement of substrate oxidation, gluconeogenesis from fructose, palmitate synthesis from fructose, plasma VLDL-kinetics) This is a randomized, double blinded study
Interventions
DIETARY_SUPPLEMENTFructose+maltodextrin placebo
DIETARY_SUPPLEMENTamino-acid + fructose
Sponsors
University of Bern
University of Lausanne
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* age 18-30 years * sex: males * BMI between 19 and 25 kg/m2 * less than 3 30min- exercise session/week
Exclusion criteria
* smokers * alcohol consumption more than 50g/week * consumption of drugs * history of diabetes in first degree relatives * presence of ferro-magnetic prosthesis, cardiac pacemakers, or any contra-indication to NMR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intrahepatic lipids | after 6 days on each controlled diet |
Secondary
| Measure | Time frame |
|---|---|
| 13C palmitate synthesis | after 6 days on each controlled diet |
Countries
Switzerland
Outcome results
None listed