Pain
Conditions
Keywords
Blood sampling, Venipuncture, Peripheral venous catheter, Complete blood count, Basic chemistry, Hemolysis, Peripheral venous catheter replaces venipuncture., Peripheral venous catheter blood sampling reduces pain.
Brief summary
We hypothesize that peripheral venous catheter used for fluid administration can replace venipuncture blood sampling for selected basic analytes and thus reduce pain in infants under 2 years of age.
Detailed description
Multiple venipunctures in hospitalized children result in physical and emotional distress. Recently, we have found that blood sampling via peripheral venous catheter used for fluid administration in children significantly reduces pain and, except for glucose, can replace venipuncture for determining complete blood count and basic chemistry analytics, including white and red blood cell counts, hemoglobin and hematocrit levels, mean corpuscular volume, mean corpuscular hemoglobin level, red blood cell distribution width, platelet count, mean platelet volume, and sodium, potassium, chloride, and urea levels (Berger-Achituv S, Budde-Schwartzman B. Ellis MH, Shenkman Z. Erez I. Blood Sampling through Peripheral Venous Catheters for Selected Basic Analytes in Children. Pediatrics. In press). The goal of this study is to investigate whether blood sampling via peripheral venous catheter used for fluid administration can significantly reduces pain and replace venipuncture for determining complete blood count and basic chemistry analytics in infants under 2 years of age.
Interventions
OTHERBlood sampling from peripheral venous catheter.
Venipuncture is performed on the opposite limb of the peripheral venous catheter. Within 3 minutes, a second sample is taken from existing peripheral venous catheter used for fluid administration. Intravenous fluids are then stopped for 30 seconds and a tourniquet applied proximal to the device for another 30 seconds. A 2-mL syringe is attached and 0.5 mL of blood aspirated and discarded. Thereafter, 2 mL blood is slowly drawn during about 15 seconds, into a different 2-mL syringe, to allow a gentle pumping action that may reduce vacuum in the syringe and thus hemolysis rates. Afterwards, the intravenous device is flushed with 2 mL normal saline and infusion restarted.
Sponsors
Meir Medical Center
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Weeks to 24 Months
Healthy volunteers
No
Inclusion criteria
* Infants under 2 years of age. * Only hemodynamically stable infants. * Infants with peripheral venous catheter present for less than 72 hours. * At least 20 mL of fluids have been infused intravenously at the time of blood sampling.
Exclusion criteria
* Infants with signs of catheter-related thrombophlebitis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To evaluate the interchangeability of peripheral venous catheter and venipuncture for complete blood count and basic chemistry indices. | Primary assessment will be done after data analysis of the first 20 participants, estimated to take up to 3 months. | Comparisons of complete blood count (including white and red blood cells, hemoglobin, hematocrit, mean corpuscular volume and hemoglobin, red cell distribution width, platelets, mean platelet volume) and basic chemistry indices (including sodium, potassium, glucose, chloride, urea) will be performed and hemolysis will be documented. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of infant's mood during procedures. | Primary assessment will be done after data analysis of the first 20 participants, estimated to take up to 3 months. | The investigator will record infant's mood (calm, distressed/crying, crying vigorously) during blood sampling from peripheral venous catheter and direct venipuncture. |
Countries
Israel
Contacts
Primary ContactErez Ilan, MD
Outcome results
None listed