Elective Obstetric or Gynecologic Surgery, Observe in Vitro Characteristics of Muscle Tissue
Conditions
Keywords
elective obstetric or gynecologic surgery
Brief summary
Analyze human skeletal muscle and learn more about the ability of adult muscle to produce myoblasts (young muscle cells).
Detailed description
Study the ability of healthy human skeletal muscle to produce myoblasts, and to determine how many cells would be needed to regenerate a certain section of injured muscle. As part of this research, we hope to gain a better understanding of the effect of age on muscle and how normal skeletal muscle can regenerate itself by producing myoblasts. The information gathered from this study will be specifically used in future research for treating Anal Incontinence.
Interventions
OTHERTissue Donation
Females over 18 who are scheduled to undergo elective surgery will have discarded tissue collected.
Sponsors
University of California, Irvine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- Age: 18 years of age or older Female Patients who are already electing to undergo obstetric or gynecologic surgery (either vaginal or abdominal) for a preexisting condition.
Exclusion criteria
\- Active systemic or pelvic infections including HIV HBV HCV, STD, PID Patients with tumors, metastatic disease or treated with cytostatics Patients undergoing emergency surgical procedures Unconscious or mentally incapable to consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cell expansion | weekly | The goal of this pilot study is to obtain small amounts of human skeletal muscle that would normally be discarded during gynecologic surgery and instead conserve this tissue for laboratory analysis. |
Countries
United States
Outcome results
None listed