Metabolic Syndrome
Conditions
Keywords
Dietary, Cross-Over Study, Lipids, Rapeseed oil, Butter, Milk Fat, Unsaturated Fat, Saturated Fat, Oxidized LDL, Platelet Function, Arterial Elasticity
Brief summary
In this study, the effects of dietary intake of cold-pressed turnip rapeseed oil (CTPRO) and milk fat are compared in men with metabolic syndrome having already participated in HMS-02 study.
Detailed description
This open and balanced cross-over study consists of two dietary treatment phases (either Virgino (R) CTPRO or butter) for 6 to 8 weeks. They are separated from each other with an eight-week washout period. At the end of both periods and 12-hour fasting an oral glucose-fat tolerance test is carried out. Except glucose, the test consists cream (after the butter phase) and CTPRO (after the CTPRO phase). Otherwise, the subjects (n=43) are asked to maintain their normal dietary habits.
Interventions
DIETARY_SUPPLEMENTCold-pressed turnip rapeseed oil (CTPRO)
1. In the dietary period of 6 to 8 weeks: CTPRO 37 ml/day. 2. In the 5-hour oral glucose and fat tolerance test: glucose and CTPRO.
DIETARY_SUPPLEMENTmilk fat
1. In dietary period of 6 to 8 weeks: 37.5 grams of butter. 2. In the 5-hour oral glucose and fat tolerance test: glucose and cream
Sponsors
Linnan Klinikka Oy
MTT Agrifood Research Finland
Finnish Red Cross Blood Service
Kanta-Häme Central Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
31 Years to 66 Years
Healthy volunteers
No
Inclusion criteria
* 43 men with metabolic syndrome having already participated in the HMS-02 Study * Willing to participate in a demanding dietary study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Circulating lipids | 6 to 8 weeks | At the end of both 6- to 8-week dietary periods, fasting values of circulating lipids including oxidized LDL are determined |
| Platelet function | 6 to 8 weeks | At the end of both 6- to 8-week dietary periods, platelet function is determined |
| Glucose tolerance | 5 hours | During a 5-hour oral glucose-fat tolerance test the area under curve of plasma glucose and insulin concentration is determined |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Arterial elasticity | 6 to 8 weeks | At the end of both 6- to 8-week dietary periods, arterial elasticity is determined |
| Serum triglyceride AUC | 5 hours | During a 5-hour oral glucose-fat tolerance test the area under curve of serum triglyceride concentration is determined |
| Platelet function | 5 hours | During a 5-hour oral glucose-fat tolerance test the platelet function is determined |
Countries
Finland
Outcome results
None listed