Endometrial Cancer
Conditions
Keywords
stage I endometrial carcinoma, stage III endometrial carcinoma
Brief summary
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research study is studying at biomarkers in tissue samples from patients with stage I or stage III endometrial cancer.
Detailed description
OBJECTIVES: * To identify microRNA expression patterns associated with lymph node metastasis in samples from patients with endometrial cancer. OUTLINE: Banked tumor tissue specimens are analyzed for microRNA expression profiling by microarray analysis and reverse transcriptase-PCR assays.
Interventions
GENETICRNA analysis
GENETICmicroarray analysis
GENETICreverse transcriptase-polymerase chain reaction
OTHERlaboratory biomarker analysis
Sponsors
National Cancer Institute (NCI)
Gynecologic Oncology Group
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Histologically confirmed endometrioid endometrial cancer * Stage IA, IB, IC, or IIIC disease * Any grade * Enrolled and evaluated on GOG-0210 Molecular Staging Study of Endometrial Cancer * Consented to allow their specimens and clinical data to be collected and stored for future research * Underwent complete surgical staging, including the following: * Hysterectomy * Bilateral oophorectomy * Washings as well as pelvic lymphadenectomy (sampling of four left and four right pelvic lymph nodes) * Para-aortic lymphadenectomy (sampling of one left and one right para-aortic lymph node) * Sufficient high-quality frozen primary tumor for testing with ≥ 75% tumor cellularity and ≤ 10% necrosis PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * See Disease Characteristics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Association between microRNA expression and lymph node metastasis | — |
Outcome results
None listed