Vasodilator Free Measure of Fractional Flow Reserve

ADenosine Vasodilator Independent Stenosis Evaluation Study (ADVISE)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01118481

Acronym

ADVISE

Enrollment

157

Registered

2010-05-06

Start date

2010-01-31

Completion date

2011-06-30

Last updated

2017-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Stenosis

Keywords

Coronary stenosis, Wave intensity analysis, Instantaneous Flow Reserve, iFR, Fractional Flow Reserve

Brief summary

Narrowing of coronary arteries interferes with blood flow and can cause chest pain. Cardiologists sometimes quantify the extent of the narrowing by measuring the fractional flow reserve (the ratio of the pressure in the aorta to the pressure downstream of the narrowing under conditions of maximal flow). We propose a new technique based on principles of wave intensity analysis (WIA) to better assess coronary stenosis and the significance of the narrowing without the need for administration of vasodilator agents such as adenosine. This would simplify assessment and improve our ability to advise patients whether stent treatment will help their symptoms.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with coronary stenosis

Exclusion criteria

* Patient's with cardiac pacemakers, valvular heart disease, and chronic renal failure * Unable to consent * Contraindications to adenosine * Contraindications to cardiac MRI

Design outcomes

Primary

Measure	Time frame
Correlation and descriptive characteristics between adenosine free measure of stenosis severity and FFR	Study end

Countries

United Kingdom

Outcome results