Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01118468

Enrollment

Registered

2010-05-06

Start date

2010-01-31

Completion date

2019-12-31

Last updated

2017-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Bypass

Keywords

Competitive Flow, Coronary artery bypass, Wave Intensity Analysis

Brief summary

Narrowing of the arteries that supply blood to the heart can lead to heart attacks and death. One way of treating this is to use artery and vein grafts from other parts of the body to bypass the narrowing. However, the blood flow from these grafts competes with flow through the natural coronary artery. This may contribute to grafts narrowing with time. This protocol aims to determine the pressure changes responsible for this effect. This could improve our understanding of why some grafts last longer than others.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with previous coronary artery bypass grafts undergoing coronary angiography and graft restudy

Exclusion criteria

* Patient's with cardiac pacemakers, valvular heart disease, and chronic renal failure * Unable to consent * Contraindications to adenosine * Contraindications to cardiac MRI

Countries

United Kingdom

Contacts

Primary ContactJustin E Davies, MRCP, PhD

justin.davies@imperial.ac.uk020 7594 33 86

Backup ContactSayan Sen, MRCP

sayan.sen@imperial.ac.uk020 7594 33 86

Outcome results