Determination of the Acute Effects of Aortic Stenosis on Coronary Artery Haemodynamics

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01118442

Enrollment

Registered

2010-05-06

Start date

2009-12-31

Completion date

2019-12-31

Last updated

2017-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Valve Stenosis

Keywords

Aortic Stenosis, Coronary Flow, Wave Intensity Analysis

Brief summary

Narrowing of the main valve which controls blood leaving the heart leads to a marked increase in death. To overcome this narrowing the heart muscle thickens abnormally and contracts more vigorously. However, in doing so, blood flow patterns to the heart muscle change through mechanisms which are incompletely understood. New technology allows such heart valve blockages to be fixed using balloons and metal stents inserted through tubes placed in arteries in the leg. Using sensors placed in these tubes it is possible to make detailed measurements of coronary flow and pressure, and apply new mathematical techniques to allow a better understanding of the detrimental effects that aortic stenosis has on coronary flow, before and after valve surgery.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Severe Aortic Stenosis undergoing TAVI * Normal coronary arteries * Normal left ventricular function * No other valvular pathology

Exclusion criteria

* Unable to consent * Left ventricular impairment * Left ventricular regional wall motion abnormality * Other valve abnormality

Countries

United Kingdom

Contacts

Primary ContactJustin E Davies, MRCP, PhD

justin.davies@imperial.ac.uk020 7594 33 86

Backup ContactSayan Sen, MRCP

sayan.sen@imperial.ac.uk020 7594 33 86

Outcome results