Diarrhea, HIV Infection
Conditions
Keywords
Diarrhea, Water, Household Water Treatment, HIV, Infant Health
Brief summary
The purpose of this study is to assess whether children under 2 years and other members of households in which HIV-positive mothers are providing replacement and complementary feeding would potentially benefit from the use of a filter designed to eliminate microbial pathogens from drinking water at the household level.
Detailed description
Contaminated drinking water is a leading cause of morbidity and mortality in low-income settings. Safe drinking water is of particular concern for HIV-positive mothers since many HIV-infected Zambian women choose replacement feeding and early cessation of breastfeeding of infants to minimize the risk of transmission of the virus. This study builds upon preliminary baseline research which determined that HIV-positive mothers would potentially benefit from an intervention that encourages HIV-positive mothers to treat their water at the household level.
Interventions
DEVICELifeStraw Family
LifeStraw Family is a household water treatment technology that will be implemented in the household to improve drinking water quality
Sponsors
University Teaching Hospital, Lusaka, Zambia
University of Zambia
Vestergaard Frandsen
London School of Hygiene and Tropical Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* Known HIV-status based on clinical testing * Have a child between 6-12 months at the initiation of the study * Within the catchment area of Kasisi or Ngwerere health clinics, Chongwe district, Lusaka
Exclusion criteria
* Lived in the catchment area less than one year or planning to move
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Use of LifeStraw Family for children under 2 and all household members | One year | Use, acceptability, and longevity of LifeStraw Family will be assessed for replacement and complementary feeds for children under 2 and for drinking water for all members of the household |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Microbiological performance of LifeStraw Family | One year | Microbiological performance of LifeStraw Family, measured in terms of thermotolerant coliforms (TTC), a well-established WHO indicator organism for faecal contamination |
| Impact of LifeStraw Family on longitudinal prevalence of diarrhea | One year | Impact of the intervention on longitudinal prevalence of diarrhoea among infants under 2 years and all household members, measured both as reported by the primary caretaker of the child and by their weight-for-age z-score (WAZ) as a proxy for diarrhoea |
Countries
Zambia
Outcome results
None listed