Local Effects of Epinephrine on Lactate, Glucose, Lipid and Protein Metabolism in Bilaterally Perfused Human Legs

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01116609

Enrollment

Registered

2010-05-05

Start date

2004-10-31

Completion date

2010-01-31

Last updated

2011-11-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Phenylalanine, Palmitate, hyperinsulinemic-euglycemic-clamp, Effects of epinephrine in healthy volunteers

Brief summary

The purpose of this study is to define the local metabolic effects of epinephrine in the bilaterally perfused human leg.

Interventions

DRUGEpinephrine

unilateral leg infusion of Epinephrine 0.4 micrograms/m2/min

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

MALE

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Male

Exclusion criteria

* Comorbidity * Females

Design outcomes

Primary

Measure	Time frame	Description
Arterio-Venous balances of metabolites	6 hours infusion	Acute regional effect of epinephrine infusion in the femoral artery

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026