Study of the Inflammatory Reaction in Standard vs Single Port Cholecystectomy for Uncomplicated Cholelithiasis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01116492

Acronym

Lap vs SILS

Enrollment

Registered

2010-05-05

Start date

2010-01-31

Completion date

2010-05-31

Last updated

2010-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cholelithiasis, Inflammatory Response

Keywords

SILS, Inflammatory reaction, a-defensins, SILS vs standard laparoscopic cholecystectomy

Brief summary

This is a study of the inflammatory reaction in standard 4 port laparoscopic cholecystectomy vs Single Port Laparoscopic (SIL) cholecystectomy. It is assumed that the reduced trauma in SIL Cholecystectomy causes reduced inflammatory reaction compared to the 4 port laparoscopic cholecystectomy.

Detailed description

Two groups of 20 patients each are included in this study. Pre operatively, 6 and 24 hours postoperatively, blood is taken from these patients, it is centrifuged and the plasma is taken. IL-6, a-defensins and CRP are measured for each sample.

Interventions

OTHERSingle incision laparoscopic cholecystectomy

One port placed through the umbilicus

OTHERLaparoscopic cholecystectomy

Standard 4 port laparoscopic cholecystectomy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Inclusion criteria

* Uncomplicated cholelithiasis * American Society of Anesthesiologists (ASA) I or II * No previous operations in upper abdomen * Body mass index (BMI) \<30

Exclusion criteria

* Cholecystitis * ASA \> II * BMI\>30 * Previous operations in upper abdomen * Previous operations in intestine

Countries

Greece

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026