The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01115218

Enrollment

Registered

2010-05-04

Start date

2009-10-31

Completion date

2012-03-31

Last updated

2018-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma, Trabeculectomy, Wound Healing

Keywords

Glaucoma

Brief summary

The aim of the study is to investigate whether it is possible to predict the success of trabeculectomy in patients with glaucoma through the examination of mediators of wound healing in anterior chamber fluid. The success rate of trabeculectomy with mitomycin C in the literature is about 75%. This leads on the question why 25% of the patients received trabeculectomy are not sufficient treated and have not a long-term IOP reduction. Precisely this question is to be examined by the study.

Interventions

PROCEDURETrabeculectomy

Trabeculectomy with mitomycin C

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients with glaucoma with a trabeculectomy required * 60 eyes of 60 patients, The ratio of female / male is not involved. * Eye pressure under local therapy: 20mmHg and above (corrected with pachymetry table). * age of at least 18 years

Exclusion criteria

* all patients not included in the group of inclusion criteria. * less than 50yl anterior chamber fluid could be collected during the operation.

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026